PTH secretion is inhibited additionally by the increased calcium uptake in the small intestine under the influence of biologically active vitamin D. The production of parathyroid hormone (PTH) in the parathyroids is inhibited directly by the biologically active form of vitamin D3. In the kidney, it inhibits the excretion of calcium and phosphate by promoting tubular resorption. The passive and active transport of phosphate is also stimulated. In the small intestine it promotes rapid and delayed calcium uptake. The company says the second part of the study will include dosing subjects for 6 hours with repeated administrations over a two-week period which can be used in its first Phase 2 study for stroke and TBI.Pharmacology: In its biologically active form Vitamin D stimulates intestinal calcium absorption, incorporation of calcium into the osteoid, and release of calcium from bone tissue. Moreau telling Proactive the committee tasked with reviewing the program has confirmed that there were no safety or tolerability issues with the highest dose, which was able to maintain plasma DMT concentrations at targeted levels and which was below the established psychedelic dose. The company is looking to investigate DMT for treatment of stroke and traumatic brain injury. Algernon Pharmaceuticals CEO Christopher Moreau joined Steve Darling from Proactive to provide an update on subsidiary Algernon NeuroScience successfully completing the highest planned single dose of its escalating Phase 1 clinical study of an intravenous formulation of AP-188 or DMT.

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